Role of Polyethylene Glycol and Silica for Dissolution Enhancement of Cefuroxime Axetil: <i>In-Vitro</i> Performance Evaluation and Characterization

Cefuroxime Axetil (CA) a widely used cephalosporin antibiotic displays low aqueous solubility and high membrane penetrability. This results in its driven variable and/or oral bioavailability therapeutic efficacy as major drawback. Thus, most of the goal our study was to increase well dissolution rate CA using simple cost-effective solid dispersion (SD) method. At first, SD formulations were prepared at various weight ratios Carplex-67 PEG-4000 by solvent evaporation technique. These new then subjected an in-vitro drug release performance tested for physicochemical characterization distinguish thermal behavior, crystallinity, interactions phenomena, surface morphology. Among formulated Solid Dispersion (CSD), CSD-8 which contained CA, Carplex-67, ratio 1:3:2, respectively showed significant (p water, Gastric Simulated Fluid (GSF), Intestinal (ISF). also < 0.001) compared marketed product. Therefore, it is supposed be promising alternative conventional antimicrobial therapy.